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目的:观察脑出血患者急性发作期、恢复期血浆内皮素(ET-1)、降钙素基因相关肽(CGRP)和神经元特异性烯醇化酶(NSE)的含量变化,探讨它们在脑出血不同时期的临床意义。方法:脑出血组60例,健康对照组60例。脑出血组分别于入院次日、第7d、第21d空腹静脉采集血液标本。用放射免疫分析ET-1、CGRP、NSE含量。结果:脑出血组各时间的ET-1、CGRP和NSE均高于健康对照组,与对照组比较,差异有统计学意义(P<0.01)。ET-1、CGRP发病次日与第7d含量比较,差异无统计学意义(P>0.05),与第21d含量比较,差异有统计学意义(P<0.01);NSE发病次日含量与第7d、21d比较,差异有统计学意义(P<0.01),第7d与第21d含量比较,无统计学意义(P>0.05)。结论:脑出血患者血浆ET-1、CGRP和NSE水平发病次日显著升高。恢复期ET-1、CGRP、NSE含量较发病次日逐渐下降。测定血浆ET-1、CGRP和NSE含量有助于脑出血患者的早期诊断和预后判断,具有重要的临床价值。
Objective: To observe the changes of plasma levels of endothelin (ET-1), calcitonin gene related peptide (CGRP) and neuron specific enolase (NSE) in patients with acute intracerebral hemorrhage (ICH) The clinical significance of different periods. Methods: 60 cases of cerebral hemorrhage group and 60 cases of healthy control group. Cerebral hemorrhage group were collected on the next day, 7d, 21d fasting venous blood samples were collected. ET-1, CGRP and NSE levels were analyzed by radioimmunoassay. Results: The levels of ET-1, CGRP and NSE in cerebral hemorrhage group were higher than those in healthy control group at each time point. The difference was statistically significant (P <0.01). There was no significant difference in the content of ET-1 and CGRP between the next day and the 7th day (P> 0.05), and the difference between the 21st and the 21st day was significant (P <0.01) (P <0.01). There was no significant difference between the 7th and 21th days (P> 0.05). Conclusion: The levels of plasma ET-1, CGRP and NSE in patients with intracerebral hemorrhage are significantly increased in the next day. The levels of ET-1, CGRP and NSE in convalescence decreased gradually on the next day after onset. Determination of plasma ET-1, CGRP and NSE levels contribute to the early diagnosis and prognosis of patients with cerebral hemorrhage, which has important clinical value.