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目的:观察还原型谷胱甘肽防治化疗药物性肝功能损害的疗效。方法:将我院近年来确诊为恶性肿瘤的217患者分为三组,GSH组与对照组共167例,为肝功能正常者。其中,GSH组有84例,在化疗同时及化疗结束后给予GSH,剂量为1.8g/d;对照组有83例,给予肌苷注射液0.4g/d,维生素C2.5g/d,连续两周后分别进行肝功能复查。将化疗药物性肝功能异常患者50例作为治疗组,应用GSH进行肝脏功能保护治疗。结果:GSH组的谷丙转氨酶(AIT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)化疗前后差值明显低于对照组(P<0.05);治疗组AST、ALT、谷氨酰转肽酶(GGT)较治疗前显著降低(P<0.05)。结论:应用GSH作为肝脏保护药物,可以预防、治疗恶性肿瘤患者的化疗药物性肝脏损害,减轻化疗的毒副作用,提高化疗患者的生活质量,保证化疗的强度,缩短化疗时间,值得临床推广应用。
Objective: To observe the efficacy of reduced glutathione in the prevention and treatment of chemotherapy-induced liver dysfunction. Methods: 217 patients diagnosed as malignant tumors in our hospital in recent years were divided into three groups, 167 cases in GSH group and control group were normal liver function. Among them, 84 cases in GSH group were given GSH at the same time and after chemotherapy, the dosage was 1.8g / d; in control group, 83 cases were given inosine injection 0.4g / d and vitamin C 2.5g / d, Weeks were reviewed liver function. 50 patients with chemotherapy-induced liver dysfunction as the treatment group, the application of GSH for liver function protection. Results: The differences of AST, AST and ALP before and after chemotherapy in GSH group were significantly lower than those in control group (P <0.05). The levels of AST, ALT, glutamyl transglutaminase Peptidase (GGT) was significantly lower than before treatment (P <0.05). Conclusion: The application of GSH as a protective drug for liver can prevent and treat chemotherapy-induced liver damage in patients with malignant tumor, reduce the toxic and side effects of chemotherapy, improve the quality of life of chemotherapy patients, ensure the intensity of chemotherapy and shorten the chemotherapy time, which is worthy of clinical application.