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目的探讨凋亡抑制基因Survivin在乳腺癌组织、癌旁乳腺组织中的表达及意义。方法用免疫组化S-P法检测80例乳腺癌组织、20例癌旁乳腺组织中Survivin的表达,分析不同病理组织间的表达关系。结果Survivin基因在乳腺癌中阳性表达率为68.75%(55/80),明显高于癌旁腺体组织(15%、3/20)的表达(P<0.05)。结论Survivin基因的抑制凋亡作用可能在乳腺癌的发生、发展过程中起重要作用,提示其可作为乳腺癌一种新的预后判断指标。
Objective To investigate the expression and significance of Survivin, an inhibitor of apoptosis, in breast cancer tissues and adjacent non-cancerous breast tissues. Methods The expression of Survivin in 80 cases of breast cancer tissues and 20 cases of adjacent non-cancerous breast tissues was detected by immunohistochemical S-P method. The relationship between different pathological tissues was analyzed. Results The positive rate of Survivin gene in breast cancer was 68.75% (55/80), which was significantly higher than that in adjacent non-cancerous tissues (15%, 3/20) (P <0.05). Conclusion The apoptosis-inhibiting effect of Survivin gene may play an important role in the occurrence and development of breast cancer, suggesting that it may serve as a new prognostic marker for breast cancer.