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生活在疟疾流行区的人们最终能产生抗疟原虫免疫力,说明发展抗疟疾疫苗是有可能的。虽然很少采用全虫疫苗免疫,但是用减毒的寄生虫免疫却是唯一诱导人类无虫免疫的方案。这个结果促使人们去寻找能产生相同保护力的亚单位疫苗,但是现在的候选亚单位疫苗没有一种能产生完全相同的保护作用。随着近来遗传修饰疟原虫的出现,人们重新关注活虫免疫。本文回顾了过去的研究,概述了这一领域的当前进展,并讨论了在进行大规模活虫免疫之前所面临的挑战。
People living in malaria-endemic areas can eventually develop immunity against the parasite, indicating that it is possible to develop anti-malarial vaccines. Although immunization with all-insect vaccines is seldom used, immunization with attenuated parasites is the only regimen that induces human insect-free immunity. This result prompted people to look for subunit vaccines that produce the same protection, but none of the current candidate subunit vaccines produce exactly the same protection. With the recent introduction of genetically modified plasmids, there has been a renewed focus on live insect immunity. This article reviews past research, outlines current advances in this area and discusses the challenges before immunization against large-scale live-worms.