Imipenem是第一个有效的半合成Thienamycin.它可与Cilastatin联用于静脉内给药.后者是增加尿排泄活性Imipenem的一种肾二肽酶抑制剂.体外研究表明Imipenem的抗菌谱极广,包括抗革蓝氏阴性和阳性需氧菌和厌氧菌,甚至对很多多重耐药菌株也有效.对产生β-内酰胺酶的细菌的作用也很强.Imipenem和等量Cilastatin联用,机体对之有很好的耐受性.已证明它们是治疗各种体内感染的有效抗菌药物,并可能是治疗 Imipenem is the first potent, semi-synthetic Thienamycin that can be used in combination with Cilastatin for intravenous administration, a nephitopeptide peptidase inhibitor that increases urinary excretion activity of Imipenem. In vitro studies have shown that Imipenem has an extremely broad spectrum of antibiotics , Including Gram-negative and positive aerobic and anaerobic bacteria, are effective even on many multidrug-resistant strains, strong against bacteria producing β-lactamase, and Imipenem, in combination with an equal amount of Cilastatin, The body is well tolerated, and they have proven to be effective antimicrobials for the treatment of various infections in the body and may be treated