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目的观察连续联合复方玄驹胶囊促排卵治疗不孕症的临床疗效。方法选取2014年4月-2015年7月在该院生殖医学中心就诊的不孕症患者72例,根据是否服用复方玄驹胶囊将其分为治疗组(52个周期)和对照组(40个周期)。观察人绒毛膜促性腺激素(hCG)日子宫内膜厚度、优势卵泡直径、优势卵泡个数、血清雌二醇(E_2)、孕酮、黄体生成素(LH)水平、周期临床妊娠率以及累计妊娠率。结果治疗组优势卵泡个数及平均每个成熟卵泡分泌E_2水平均明显优于对照组,差异均有统计学意义(P<0.05)。hCG日子宫内膜厚度、优势卵泡直径、妊娠率及累计妊娠率均有所提高,但差异无统计学意义(P>0.05)。结论促排卵指导同房的不孕症患者添加复方玄驹胶囊口服治疗有一定疗效,可明显增加优势卵泡个数及平均每个成熟卵泡分泌E_2水平,并可在一定范围内增加子宫内膜厚度,连续用药可提高累计妊娠率。
Objective To observe the clinical efficacy of continuous combined with Xuanju Capsule in ovulation induction treatment of infertility. Methods Seventy-two patients with infertility who were admitted to the Reproductive Medicine Center from April 2014 to July 2015 were divided into treatment group (52 cycles) and control group (40 patients) according to whether they took Xuanju capsule cycle). The endometrial thickness, dominant follicle diameter, number of dominant follicles, serum estradiol (E2), progesterone and luteinizing hormone (LH), cycle clinical pregnancy rate and cumulative Pregnancy rate. Results The number of dominant follicles in the treatment group and the average secretion of E 2 per mature follicle were significantly better than those in the control group (P <0.05). The endometrial thickness, the dominant follicle diameter, the pregnancy rate and the cumulative pregnancy rate increased on the hCG day, but the difference was not statistically significant (P> 0.05). Conclusion Ovulation guidance in the same room of infertility patients with compound Xuanju capsule oral treatment has a certain effect, can significantly increase the number of dominant follicles and the average secretion of each mature follicle E 2 levels, and within a certain range to increase the thickness of the endometrium, Continuous medication can increase the cumulative pregnancy rate.