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以往10年中,有数种新的有效药物用于治疗室性心律失常。慢心律为其中最为广泛研究之一,该药属Vaughan-Williams分类法的第一类。它对蛙的坐骨神经是一种强的局部麻醉剂。对游离心房和心室肌以及浦顷野氏纤维,慢心律减低其动作电位除极的最大速率,增加兴奋阈值,减慢传导速度,并延长有效不应期,而对静息期膜电位或窦房结自律性几无作用。慢心律的这些作用与利多卡因者相似;两药使浦顷野氏纤维的动作电位间期随浓度增加而渐缩短。相反,奎尼丁、普鲁卡因酰胺
In the past 10 years, there are several new and effective drugs for the treatment of ventricular arrhythmias. Slow heartbeat is one of the most widely studied and is the first of the Vaughan-Williams classification. It is a strong local anesthetic to the frog’s sciatic nerve. On the free atrium and ventricular muscle and Pu are wild fibers, slow heart rhythm to reduce the maximum rate of its action potential depolarization, increase the excitement threshold, slow down the conduction and prolong the effective refractory period, and resting membrane potential or sinus End home self-regulation has no effect. These effects of slow rhythm are similar to those of lidocaine; the two drugs cause the duration of action potentials of Poshi’s fibers to shorten as the concentration increases. In contrast, quinidine, procainamide