贲门失弛缓症是一种少见的原发性食管动力障碍性疾病，以食管下段括约肌松弛功能受损为特征。该病药物治疗效果不佳，而手术治疗风险较大，并发症多。近年来，内镜下治疗因其疗效肯定、并发症少逐渐成为治疗贲门失弛缓症的一线治疗方法，尤其是内镜下肌切开术以其媲美手术治疗的疗效被越来越多的临床医师采用。然而，国内外对内镜下治疗贲门失弛缓症适应证的选择及其确切疗效等尚未达成共识。“,”Achalasia is a rare primary esophageal motility disorder, which is featured with impaired relaxation of the lower esophageal sphincter.Nowadays there is no ideal medication treatment for this disease, while operation is too risky with multiple complications .Over the past few years,peroral endoscopic myotomy ( POEM) has been widely adopted as a clinical approach in practice,and has gradually become the first-line treatment,for it brings affirmative effects and less complications, equaling the operation.However, there remains no consensus on the indications and definite effects of POEM at home and abroad .