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目的:分析母亲孕期和产后抑郁情绪对儿童情绪和行为的影响。方法:在PubMed、Embase、Web of Knowledge、PsycINFO、Cochrane、万方数据库和中国知网，以“母亲(maternal) AND抑郁(depression) AND儿童或子代(child OR offspring) AND神经心理(neuropsychology)”为检索词检索有关母亲抑郁情绪对子代情绪和行为产生影响的病例对照研究和队列研究，检索时间为2000年1月1日至2020年10月31日。根据纳入标准和排除标准筛选文献，采用RevMan 5.3进行n Meta分析。n 结果:共纳入14篇文献，包括病例组3 914例，对照组17 016例。结果显示，母亲在孕期或产后存在抑郁情绪，儿童罹患情绪或行为障碍的风险是母亲无抑郁情绪儿童的2.03倍(n OR＝2.03，95%n CI：1.55~2.65)；孕期和产后抑郁情绪均可增加子代情绪或行为障碍的发生风险，但2个时期的差异无统计学意义(n Z＝-0.371，95%n CI：0.796~1.168)；这种影响可持续至子代学龄前和学龄期，且学龄期儿童发生情绪或行为障碍的风险大于学龄前期(n Z＝-2.340，95%n CI：0.643~0.962)。n 结论:孕期和产后抑郁情绪均会增加子代情绪或行为障碍的发生风险，而且这种影响不会随着年龄的增长而减少。“,”Objective:To evaluate the effect of maternal depressed mood at pregnancy and postpartum on the risk of emotional or behavioral disorders of offspring by n meta-analysis.n Methods:The following Mesh words and free words were searched in 7 online databases, including the PubMed, Embase, Web of Knowledge, PsycINFO, Cochrane, WanFang databases and China National Knowledge Infrastructure from January 1, 2000 to October 31, 2020: “ maternal” AND “ depression” AND “ child OR offspring” AND “ neuropsychology” . According to the inclusion and exclusion criteria, case-control and cohort studies reporting the effect of maternal depressed mood during pregnancy or postpartum on the risk of emotional or behavioral disorders of offspring were reviewed. n Meta-analysis was performed by RevMan 5.3.n Results:Fourteen studies involving 3 914 in the case group and 17 016 in the control group were included.Children whose mother with depressed mood during pregnancy or postpartum had 2.03 times risk of emotional or behavioral disorders than those whose mothers without depressed mood (n OR=2.03, 95%n CI: 1.55-2.65). Both depressed mood at pregnancy and postpartum could increase the incidence of emotional or behavioral disorders in children, but there was no significant difference between these two periods (n Z=-0.371, 95%n CI: 0.796-1.168). Moreover, the effect of maternal depressed mood on emotional or behavioral disorders in offspring could last to the preschool and school period, and the children in the school period may have higher incidence of emotional or behavioral disorders than those during the preschool period (n Z=-2.340, 95%n CI: 0.643-0.962).n Conclusions:Maternal depressed mood can increase the incidence of emotional or behavioral disorders in offspring, which are long-lasting and do not decrease with age.