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肾细胞癌出现未分化(间变性)和横纹肌样细胞特征时被公认为预后不良,其分子机制尚未充分阐明。近期研究发现SWI/SNF染色质重塑复合体是不同器官具有未分化和横纹肌样特征癌的分子机制。本文对32例未分化肾细胞癌(均具有未分化和明显横纹肌样特征,可有或无普通型肾细胞癌成分)的分子特征进行分析。所有病例除常规肾细胞癌标志物外均加染SWI/SNF通
Renal cell carcinoma is considered as a poor prognosis in the presence of undifferentiated (anaplastic) and striated muscle-like cell features, and its molecular mechanism has not yet been fully elucidated. Recent studies have found that SWI / SNF chromatin remodeling complex is the molecular mechanism of different organs with undifferentiated and rhabdomyosarcoma. In this paper, 32 cases of undifferentiated renal cell carcinoma (both undifferentiated and rhabdomyosarcomatous features, with or without common type of renal cell carcinoma) molecular characteristics were analyzed. In addition to conventional renal cell carcinoma markers in all cases were added with SWI / SNF pass