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目的 从抗利尿激素(ADH)、醛固酮(ALD)、心钠素(ANP)及红细胞内 Na+、K+等的变化来探索湿阻中焦证水盐代谢的调节机制,并观察平胃散对它们的影响。方法 塑造湿阻中焦证模型,将大鼠分为正常组、湿阻造模组、平胃散组及自然恢复组,采用放免法检测血浆 ADH、ALD 及 ANP 的浓度,用电解质分析仪测定细胞内 Na+、K+。结果 与正常组比较,湿阻造模组大鼠 ADH 显著升高(P<0.01),ALD 有明显升高的趋势,ANP 无显著性差异,Na+明显升高(P<0.05),K+明显降低(P<0.01);治疗后,平胃散组和自然恢复组与湿阻造模组比较,ADH 和 ALD 显著下降(P<0.01),ANP 无显著性差异,Na+明显降低(P<0.01),K+无显著性差异。结论 湿阻中焦证大鼠 ADH 的释放增强,ALD的分泌有增强的趋势,ADH、ALD 共同参与了湿阻中焦证水、电解质平衡的调节,使机体内水、钠潴留,钾排泄,而心钠素并不参与湿阻中焦证代谢的调节;平胃散可通过抑制湿阻中焦证大鼠 ADH 的释放和 ALD 的分泌,调节机体水、电解质平衡的紊乱,起到保钾排钠的作用。
Objective To explore the regulatory mechanisms of water and salt metabolism in the dampness resistance of vasodilative hormone (ADH), aldosterone (ALD), atrial natriuretic peptide (ANP) and Na+ and K+ in red blood cells. Observe the effects of Pingwei San on them. influences. METHODS: The damp-resistance and coke model was established. Rats were divided into normal group, dampness-resistance model group, Pingweisan group and natural recovery group. Plasma concentrations of ADH, ALD and ANP were measured by radioimmunoassay, and cells were measured by an electrolyte analyzer. Na+, K+. Results Compared with the normal group, the ADH of rats in the dampness-resistance model group was significantly higher (P<0.01), ALD was significantly increased, ANP was not significantly different, Na+ was significantly increased (P<0.05), and K+ was significantly decreased. (P<0.01); After treatment, ADH and ALD decreased significantly (P<0.01), ANP had no significant difference, and Na+ decreased significantly (P<0.01) in Pingweisan group and natural recovery group compared with the wet resistance model group. There was no significant difference in K+. Conclusions The release of ADH from rat with coke-induced prostaglandin in dampness is enhanced, and the secretion of ALD is increased. ADH and ALD are involved in the regulation of water and electrolyte balance in the dampness of coke, resulting in water, sodium retention, and potassium excretion. The atrial natriuretic peptide is not involved in the regulation of focal metabolism in dampness resistance; Pingweisan can regulate the release of ADH and the secretion of ALD in rats with dampness resistance, regulate the disturbance of body’s water and electrolyte balance, and play a role in protecting potassium. The role of sodium.