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目的探讨卵黄囊的声像图特点及CA125的变化规律在预测早期流产中的价值。方法使用超声对早孕孕妇卵黄囊的形态、大小等特点进行观察,同时采用化学发光法对其CA125水平进行监测。结果难免流产组卵黄囊的测量值与正常早孕组相比,差异有显著性(P<0.05);难免流产组CA125值明显高于正常早孕组及继续妊娠组(P<0.01);且难免流产组卵黄囊大小与CA125值呈负相关(r=-0.695,P<0.05),卵黄囊预测流产的敏感性、特异性分别为80.76%,89.47%;CA125预测流产的敏感性、特异性分别为92.30%,88.89%;两者联合检测预测流产的敏感性、特异性分别为98.51%,79.21%。结论卵黄囊和CA125与早期流产的发生、发展及预后密切相关;联合测定卵黄囊和CA125有助于早期流产的诊断。
Objective To investigate the characteristics of yolk sac and the changes of CA125 in the prediction of early abortion. Methods Ultrasound was used to observe the shape, size and other characteristics of yolk sac in early pregnant women, and the chemiluminescence method was used to monitor the level of CA125. The results of inevitable abortion group yolk sac measurement compared with normal early pregnancy group, the difference was significant (P <0.05); inevitable abortion group CA125 value was significantly higher than the normal pregnancy group and the continuous pregnancy group (P <0.01); and inevitable abortion The size of yolk sac was negatively correlated with CA125 (r = -0.695, P <0.05). The sensitivity and specificity of yolk sac for predicting miscarriage were 80.76% and 89.47% respectively. The sensitivity and specificity of CA125 in prediction of miscarriage were 92.30% and 88.89% respectively. The sensitivity and specificity of the combined detection and prediction of the two methods were 98.51% and 79.21% respectively. Conclusion The yolk sac and CA125 are closely related to the occurrence, development and prognosis of early miscarriage. The combined determination of yolk sac and CA125 is helpful for the diagnosis of early miscarriage.