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目的:探讨不同类型缺血性脑血管病患者血浆同型半胱氨酸(Hcy)水平及其与神经功能缺损程度的关系。方法:对缺血性脑血管病患者85例(53脑梗死患者和32例TIA患者)和对照组20例,酶联免疫吸附法检测血浆Hcy水平;采用美国国立卫生院制订的标准(NIHSS评分)对脑梗死神经功能缺损程度进行评定,对血浆Hcy与缺血性脑血管病相关性进行分析。结果:缺血性脑血管病、脑梗死与TIA患者血浆Hcy水平均高于对照组,脑梗死与TIA患者血浆Hcy水平相比无明显差异;血浆Hcy水平与NIHSS评分无明显相关性。结论:缺血性脑血管病(包括脑梗死、TIA)患者血浆Hcy水平升高,Hcy水平可能与脑缺血的发生有关,与缺血时间及神经功能缺损程度无关;Hcy水平升高可能是缺血性脑血管病的独立危险因素之一。
Objective: To investigate the relationship between plasma homocysteine (Hcy) levels and the degree of neurological deficits in patients with different types of ischemic cerebrovascular diseases. Methods: Totally 85 patients with ischemic cerebrovascular disease (53 with cerebral infarction and 32 with TIA) and 20 healthy controls were enrolled in this study. Plasma homocysteine (Hcy) levels were measured by enzyme-linked immunosorbent assay (ELISA). The NIHSS score ) To assess the extent of neurological deficits in cerebral infarction, plasma Hcy and ischemic cerebrovascular disease were analyzed. Results: Plasma Hcy levels in patients with ischemic cerebrovascular disease, cerebral infarction and TIA were higher than those in control group. There was no significant difference in plasma Hcy levels between cerebral infarction and TIA patients. There was no significant correlation between plasma Hcy and NIHSS scores. Conclusions: Plasma Hcy level is increased in patients with ischemic cerebrovascular disease (including cerebral infarction, TIA). The level of Hcy may be related to the occurrence of cerebral ischemia, and has no relation with the ischemic time and the degree of neurological deficit. Hcy level may be One of the independent risk factors of ischemic cerebrovascular disease.