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目的 探讨小剂量 (≤ 50 mg)脱氢表雄酮硫酸酯 ( DS)对老年男性记忆力的影响。 方法 双盲对照观察老年男性 64例口服 DS 3个月后记忆力的变化 ,其中治疗 A组每天口服 DS 2 5mg、治疗 B组每天 50 mg。以放免法测定治疗前后血清脱氢表雄酮 ( DHEA)和 DS,韦氏记忆量表测定记忆商 ( MQ)。 结果 治疗 A组 3个月后较服药前 DS提高 ( 2 .7± 0 .5) nmol/ L,MQ提高 ( 1 4 .6±6.1 )分 ( P<0 .0 1 ) ;治疗 B组 3个月后较服药前 DS提高 ( 4.4± 1 .5) nmol/ L,MQ提高 ( 1 2 .2± 8.7)分( P<0 .0 1 )。两治疗组 MQ均较对照组明显提高 ( P<0 .0 1 )。 结论 口服小剂量 DS对老年男性的记忆力有一定的改善作用。
Objective To investigate the effect of low dose (≤ 50 mg) dehydroepiandrosterone sulphate (DS) on memory in elderly men. Methods The changes of memory in 64 elderly patients with oral DS after 3 months were observed by double-blind control. The treatment group A received 5 mg DS 2 daily and 50 mg daily. The levels of serum DHEA and DS before and after treatment were determined by radioimmunoassay. The Wechsler Memory Scale (MQ) was measured. Results After treatment for 3 months, the level of DS increased (2. 7 ± 0.5) nmol / L and the level of MQ increased (14.6 ± 6.1) (P <0.01) Compared with before treatment, DS increased (4.4 ± 1.5) nmol / L and MQ increased (12.2 ± 8.7) points (P <0.01). MQ in both treatment groups was significantly higher than that in control group (P <0.01). Conclusion Oral administration of low-dose DS can improve the memory of elderly men.