早在一百年前就育人发现体温升高可以使某些肿瘤消退。1884年Bruns报告1例晚期黑色素瘤患者在感染丹毒高热(40℃以上)后,肿瘤自然消失。以后Coley(1893年)报告38例晚期癌患者,在感染丹毒长期高热以后,其中12例患者的肿瘤消失。1916年Percy用局部热处理,治疗子宫癌,其中6例晚期患者经治疗存活3～7年。Rohdenburg As early as a hundred years ago, it was discovered that elevated body temperature can cause certain tumors to subside. In 1884, Bruns reported that in 1 patient with advanced melanoma, the tumor disappeared naturally after erysipelas fever (above 40°C). Later, Coley (1893) reported 38 patients with advanced cancer. After long-term hyperthermia with erysipelas, tumors of 12 patients disappeared. In 1916 Percy used local heat treatment to treat uterine cancer, of which 6 cases of advanced patients survived for 3 to 7 years after treatment. Rohdenburg