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为确定汞蒸汽对肾脏损害的早期亚临床表现 ,对从事汞电池制造的男、女工人 (暴露组 )测量了尿、血和头发中的总汞浓度 ,同时对尿 N-乙酰基 -β- D-氨基葡萄糖苷酶活性和蛋白浓度也进行了测定。对照组是未接触汞蒸汽的同厂工人 ,对其尿总汞浓度、尿蛋白、NAG活性进行了测定。研究结果显示 ,在暴露组观察到显著的正相关 ,但对照组未发现。对照组和暴露组在尿总汞浓度、N-乙酰基 - β- D-氨基葡萄糖苷酶活性、蛋白质浓度上无显著差别。在暴露组中 ,从事汞作业以来尿总汞浓度没有增加。个体汞暴露水平从 0 .0 0 1～ 0 .0 0 8mg/ m3。结论为 ,尿蛋白和 N-乙酰基 - β- D-氨基葡萄糖苷酶活性正相关可能是比尿总汞和 /或 NAG活性对进行性肾小管损伤更为灵敏的指标之一。
To determine the early subclinical manifestations of mercury vapor damage to the kidneys, total mercury concentrations in urine, blood and hair were measured for male and female workers engaged in mercury cell manufacture (exposed group), and urine N-acetyl-β- D-glucosaminidase activity and protein concentration were also determined. The control group was the same factory workers who did not contact with mercury vapor, and the urine total mercury concentration, urine protein and NAG activity were measured. The results showed a significant positive correlation was observed in the exposed group but not in the control group. There were no significant differences between the control group and the exposed group in total urinary mercury concentrations, N-acetyl-β-D-glucosaminidase activity, and protein concentration. In the exposure group there was no increase in urinary total mercury concentration after mercury exposure. Individual mercury exposure levels ranged from 0.0001 to 0.080 mg / m3. Conclusions: The positive correlation between urinary protein and N-acetyl-β-D-glucosaminidase activity may be one of the more sensitive indicators of progressive renal tubular injury than urinary total mercury and / or NAG activity.