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[目的]探讨乳腺导管原位癌伴早期浸润(DCIS-Ei)的临床特征和预后。[方法]回顾性收集1999年1月至2005年12月收治的79例不伴腋窝淋巴结转移的乳腺DCIS-Ei患者的临床资料,应用单因素分析影响预后的因素。[结果]中位随访时间为10.3年,3例患者出现乳腺癌相关复发(BCRR),包括1例区域淋巴结转移,1例同时出现区域淋巴结和远处转移,1例对侧原发乳腺癌。10年累积BCRR率为5.3%。单因素预后分析结果显示,病灶>5.0cm(P=0.004)和原位癌成分内分泌受体(HR)阴性(P=0.011)是显著增加BCRR的因素。[结论 ]乳腺DCIS-Ei的长期预后良好,很少出现BCRR,病灶>5.0cm和HR阴性者容易发生BCRR。
[Objective] To investigate the clinical features and prognosis of ductal carcinoma in situ with early invasion (DCIS-Ei). [Methods] The clinical data of 79 patients with DCIS-Ei in breast without axillary lymph node metastasis from January 1999 to December 2005 were collected retrospectively. Univariate analysis was used to analyze the prognostic factors. [Results] The median follow-up time was 10.3 years. Breast cancer-related relapse (BCRR) occurred in 3 patients, including 1 case of regional lymph node metastasis, 1 case of regional lymph node and distant metastasis, and 1 case of contralateral primary breast cancer. The 10-year cumulative BCRR rate was 5.3%. Univariate prognostic analysis showed that lesions> 5.0 cm (P = 0.004) and carcinoma in situ (HR) negative (P = 0.011) were significant contributors to BCRR. [Conclusion] The long-term prognosis of breast DCIS-Ei is good, BCRR rarely occurs, BCRR is easy to occur in lesions> 5.0cm and HR negative.