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目的了解2012—2013年深圳市Beau线/甲脱落的临床特点及其与手足口病(HFMD)的关联情况,并复习相关文献。方法对近2年在本院皮肤科、儿科、传染科门诊诊治的HFMD及Beau线/甲脱落患者临床资料进行分析。结果 295例患者中女157例,男138例,平均发病年龄4.25岁,患者均有发热、皮损,皮损消退中位时间为8.7 d(7~14 d)。对其中80例患者行病原学检查,咽拭子聚合酶链反应(PCR)核酸扩增检测,肠病毒71(EV71)28例(35.00%),柯萨奇病毒A16(CA16)7例(8.75%),其他肠病毒5例(6.25%),其余无阳性结果。随访中发现HFMD发病后的4~6周有35例出现了甲损害,这些患者此前均无甲外伤、甲周炎等病史,所有患者甲损害在6周内均恢复。结论与HFMD相关的Beau线/甲脱落机制尚不清楚,且由于其症状较轻,并可自愈,故无需治疗。
Objective To investigate the clinical characteristics of Beau-sarcolepsy in Shenzhen in 2012-2013 and their association with HFMD, and to review the relevant literature. Methods The clinical data of HFMD and Beau-A patients who were diagnosed as dermatology, pediatrics and infectious diseases in our hospital in the past two years were analyzed. Results Among 295 patients, 157 were female and 138 were male, with an average age of 4.25 years. All patients had fever, skin lesions and skin lesions regression. The median time was 8.7 days (ranged from 7 to 14 days). Eighty patients underwent etiological examination, throat swab polymerase chain reaction (PCR) detection of nucleic acid amplification, 28 cases (35.00%) of enterovirus 71 (EV71), 7 cases of Coxsackie virus A16 %), Other enterovirus in 5 cases (6.25%), the rest without positive results. During follow-up, 35 cases of nail damage occurred in 4 to 6 weeks after onset of HFMD. None of the patients had previous history of nail damage and peri-peritonitis, and all of the patients recovered in 6 weeks. Conclusions The Beau line / a shedding mechanism associated with HFMD is not known and is not treated because of its mild symptoms and self-healing.