论文部分内容阅读
目的：介绍国内外透皮吸收制剂最新研究进展，为我国制剂研究提供参考。方法：以国内外大量有代表性的论文为基础，进行分析、整理和归纳。结果：综述了透皮吸收理论的新进展，透皮吸收动力学可通过隔室模型进行描述。介绍了几种透皮吸收促进方法：离子导入法和超声波导入法；吸收促进剂月桂氮酮的最佳浓度确定方法和新的吸收促进剂；脂质体用于透皮治疗；化学修饰及肽和（或）蛋白质类药物的透皮吸收和激光促进药物透皮吸收等方法研究成果和进展。结论：透皮吸收制剂具有广阔前景。
Objective: To introduce the latest research progress of transdermal absorption preparations at home and abroad and provide reference for the study of preparations in China. Methods: Based on a large number of representative papers at home and abroad, analysis, collation and induction were conducted. RESULTS: The new progress of transdermal absorption theory was reviewed. The transdermal absorption kinetics can be described by the compartment model. Several methods for the promotion of transdermal absorption were introduced: iontophoresis and ultrasound introduction; determination of the optimal concentration of absorption enhancer laurinone and new absorption enhancers; liposomes for transdermal treatment; chemical modification and Transdermal absorption of peptides and/or protein drugs and laser-assisted transdermal absorption of drugs. Research results and progress. Conclusion: Transdermal absorption preparations have broad prospects.