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目的和方法：本研究采用大鼠可逆性阻塞大脑中动脉所致的局灶性脑缺血再灌流模型，观察缺血３ｈ再灌流３ｈ、缺血６ｈ再灌流３ｈ对脑组织脑局部血流量（ｒｅｇｉｏｎａｌｃｅｒｅｂｒａｌｂｌｏｏｄｆｌｏｗ，ｒＣＢＦ）、ＡＴＰ、乳酸及脑水含量的影响。结果：缺血３ｈｒＣＢＦ明显下降（Ｐ＜００１），再灌流３ｈ升至缺血前６５３％（Ｐ＜００１）。缺血３ｈ再灌流３ｈ与缺血６ｈ组比较，ＡＴＰ明显恢复（Ｐ＜００１），乳酸含量明显下降（Ｐ＜００１），脑水含量明显减少（Ｐ＜００５）。缺血６ｈ再灌流３ｈ与缺血９ｈ组比较，尽管ＡＴＰ明显恢复（Ｐ＜００１），乳酸含量下降（Ｐ＜００１），但脑水含量无显著差异（Ｐ＞０１）。结论：缺血３ｈ再灌流３ｈ保护“半暗带”的效果优于缺血６ｈ再灌流３ｈ。
PURPOSE AND METHODS: In this study, a rat model of focal cerebral ischemia and reperfusion induced by obstruction of the middle cerebral artery was used in this study. The reperfusion of 3h after ischemia, 3h of reperfusion, 3h of reperfusion of 6h after ischemia, regionalcerebralbloodflow, rCBF), ATP, lactic acid and brain water content. Results: The ischemic 3hrCBF decreased significantly (P <001), and reached the level of 653% before reperfusion (P <001) 3h after reperfusion. Compared with ischemic 6h group, ATP obviously recovered (P <001), the content of lactic acid decreased significantly (P <001), and the content of brain water decreased obviously (P <005). There was no significant difference in brain water content between 6 h ischemia reperfusion 3 h and ischemia 9 h group (P 0. 01), although there was a significant recovery of ATP (P 0. 01) and lactate content (P 0. 01) . Conclusion: The protective effect of “penumbra” 3h after reperfusion for 3h after ischemia is better than that of 6h reperfusion for 3h.