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Graves病患者血循环中存在过量的甲状腺激素，可刺激成骨细胞活性，促进骨基质的吸收，导致骨代谢紊乱，造成代谢性骨病。传统的骨形成指标——血清AKP和骨吸收指标——血浆TRAP、尿HOP／Cr和Ca／Cr的灵敏度和特异性都低。80年代和90年代初国外采用血清骨钙素（Bone－Gla－Prot
Excess thyroid hormones in the blood circulation of patients with Graves’ disease can stimulate the activity of osteoblasts, promote the absorption of bone matrix, lead to disorder of bone metabolism and cause metabolic bone disease. Traditional bone formation indicators - serum AKP and bone mineral density indicators - plasma TRAP, urinary HOP / Cr and Ca / Cr sensitivity and specificity are low. In the 1980s and early 90s abroad, serum osteocalcin (Bone-Gla-Prot