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自六十年代麻疹疫苗问世后,麻疹的预防收到良好效果。目前一些发达国家已基本消除麻疹,但在发展中国家仍有麻疹流行,每年有几十万儿童死于麻疹。我国于六十年代使用麻疹疫苗后,很快把发病率从100/10万以上下降到100/10万左右。但此后尽管接种率很高,发病率却不再下降,且部分地区有小流行。经研究证实其根本原因是麻疹疫苗热稳定差,又无完善的冷链系统。接种失效的麻疹疫苗起不到预防作用。所以提高麻疹疫苗的热稳定性是急待解决的关键问题。1982年WHO对麻疹疫苗的热稳定性做了新规定,它要求疫苗于37℃下置7天
Since the advent of measles vaccine in the 1960s, measles prevention has received good results. At present, some developed countries have basically eliminated measles. However, measles is still endemic in developing countries and hundreds of thousands of children die from measles each year. After using measles vaccine in the 1960s, our country quickly reduced the incidence from above 100 / 100,000 to about 100 / 100,000. However, although the vaccination rate was high thereafter, the incidence rate did not decrease any more and there was a small epidemic in some areas. The study confirmed that the root cause of measles vaccine is poor thermal stability, there is no perfect cold chain system. Vaccination fails measles vaccine can not play a preventive role. Therefore, to improve the thermal stability of measles vaccine is an urgent solution to the key issues. The 1982 WHO made a new regulation on the thermostability of measles vaccine, which requires the vaccine to be kept at 37 ° C for 7 days