Objective To study the population pharmacokinetic(PPK)profiles of linezolid in Chinese healthy volunteers and infected patients.Methods Linezolid 600 mg was administered to 31 Chinese healthy volunteers with a single dose and to 57 infected patients every 12 h for at least5 doses.High performance liquid chromatography was applied to determine the plasma concentration of linezol- Objective To study the population pharmacokinetic (PPK) profiles of linezolid in Chinese healthy volunteers and infected patients. Methods Linezolid 600 mg was administered to 31 infected healthy individuals with a single dose and to 57 infected patients for 12 h for at least 5 doses. High performance liquid chromatography was applied to determine the plasma concentration of linezol-