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为了探讨青年人胃癌的治疗效果和预后影响因素,作者对1984年6月~1990年11月间收治的60例35岁以下青年人胃癌随访资料进行回顾性分析。本组占同期收治胄癌总数的7.4%,男女比例为1:1.5。56例经手术治疗,切除48例(85.7%),其中根治切除41例(73.2%),随访率100%。全组5年生存率为28.3%,根治切除组为39%,高于姑息切除和未切除组。淋巴清扫范围对早期病例5年生存率影响,统计学无显著性差异。早期与进展期间5年生存率差异P<0.01。不规则口服化疗5年生存率低于未化疗者,P<0.05或P<0.01。病变部位、组织学类型、性别对生存率无影响,P>0.05。作者认为早期诊断和根治性切除是提高生存率的关键,我们不主张不规则口服化疗。
In order to explore the therapeutic effects and prognostic factors of young patients with gastric cancer, the authors retrospectively analyzed the follow-up data of 60 patients with gastric cancer under 35 years of age admitted between June 1984 and November 1990. This group accounted for 7.4% of the total number of cancers treated in the same period, male to female ratio was 1:1.5. 56 cases were treated by surgery, 48 cases (85.7%) were removed, 41 of them were radical resection (73.2%) The follow-up rate was 100%. The 5-year survival rate was 28.3% in the whole group and 39% in the radical resection group, which was higher than the palliative resection and unresectation groups. There was no statistically significant difference in the effect of lymphatic dissection range on the 5-year survival rate of early cases. The 5-year survival rate difference between early stage and advanced stage was P<0.01. The 5-year survival rate of irregular oral chemotherapy was lower than those without chemotherapy, P<0.05 or P<0.01. Lesions, histological types, and gender had no effect on survival, P>0.05. The authors believe that early diagnosis and radical resection are the key to improve survival. We do not advocate irregular oral chemotherapy.