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目的：探讨rasP21蛋白在卵巢交界性肿瘤（OBT）中的表达及其临床意义。方法：应用免疫组织化学SP法对41份OBT中rasP21蛋白的表达进行检测，同时选取10份正常卵巢组织、20份卵巢上皮性良性肿瘤、24份卵巢上皮性癌标本作对照研究。结果：rasP21在OBT中的阳性表达率为43．9％，与正常卵巢组织、卵巢良性肿瘤及卵巢癌相比，其阳性表达率及强度差异均有显著性，随着病变恶性程度提高，表达逐渐增强（P＜0．05），粘液性OBT与卵巢粘液性良性肿瘤及卵巢恶性肿瘤相比，阳性表达率及表达强度差异均有显著性（P＜0．05），而浆液性OBT与同种病理类型的其他卵巢肿瘤相比，未见上述结果。除rasP21的表达强度与OBT肿瘤大小有关外，其表达结果与OBT的其他临床病理因素均无关（P＞0．05）。结论：rasP21表达与OBT的发生有关，检测rasP21蛋白有助于粘液性OBT与其他卵巢粘液性肿瘤的鉴别。
Objective: To investigate the expression of rasP21 protein in borderline ovarian tumors (OBT) and its clinical significance. Methods: The expression of rasP21 protein in 41 OBT specimens was detected by immunohistochemical SP method. Meanwhile, 10 normal ovarian tissues, 20 benign epithelial ovarian tumors and 24 ovarian epithelial carcinoma specimens were selected as the control study. Results: The positive expression rate of rasP21 in OBT was 43.9%. Compared with normal ovarian tissue, benign ovarian tumor and ovarian cancer, the positive rate and intensity of rasP21 were all significantly different. With the increase of malignant degree of rasP21, the expression of rasP21 (P <0.05). The positive expression rate and the expression intensity of mucinous OBT in ovarian mucinous benign tumor and ovarian cancer were significantly different (P <0.05), but serous OBT and The same type of pathology compared to other ovarian tumors, the above results were not seen. Except rasP21 expression intensity and OBT tumor size, the expression of OBT and other clinical pathological factors have nothing to do (P> 0.05). Conclusion: The expression of rasP21 is associated with the occurrence of OBT. The detection of rasP21 protein is helpful for the differential diagnosis between mucinous OBT and other ovarian mucinous tumors.