目的探讨胶体果胶铋联合奥美拉唑治疗反流性食管炎的(RE)的有效性。方法 75例经内镜证实的RE患者随机分为两组,治疗组37例,予以胶体果胶铋150mg,3次/d,奥美拉唑20mg,2次/d;对照组38例,予以奥美拉唑20mg,2次/d,口服,治疗4周。分别于治疗前后观察烧心、反酸、胸骨后疼痛等症状变化,复查内镜观察镜下食管炎痊愈率。结果治疗4周后,两组临床症状改善情况,治疗组显效27例,有效8例,有效率为94.6%;对照组显效13例,有效15例,有效率为73.7%,两组在症状缓解率方面差异有统计学意义(P<0.05)。治疗组食管炎内镜下疗效,显效率为72.9%,有效率为97.3%,对照组显效率为47.4%,有效率为58.6%。两组内镜下疗效差异有统计学意义(P<0.01)。结论胶体果胶铋联合奥美拉唑治疗反流性食管炎疗效优于单用奥美拉唑。 Objective To investigate the effectiveness of colloidal bismuth pectin combined with omeprazole in the treatment of reflux esophagitis (RE). Methods Seventy-five patients with RE confirmed by endoscopy were randomly divided into two groups. The treatment group consisted of 37 patients with colloidal bismuth pectin 150 mg three times daily and omeprazole 20 mg twice daily, and 38 patients in the control group Omeprazole 20mg, 2 times / d, orally, for 4 weeks. Respectively before and after treatment to observe the heartburn, acid reflux, sternum pain and other symptoms, review endoscopic observation of esophagitis cure rate. Results After 4 weeks of treatment, the clinical symptoms were improved in both groups. In the treatment group, 27 cases were markedly effective and 8 cases were effective. The effective rate was 94.6%. In the control group, 13 cases were markedly effective and 15 cases were effective. The effective rate was 73.7% Rate differences were statistically significant (P <0.05). Efficacy of endoscopic treatment of esophagitis in the treatment group was 72.9%, the effective rate was 97.3%, the effective rate was 47.4% in the control group, the effective rate was 58.6%. There was significant difference between the two groups in endoscopic treatment (P <0.01). Conclusion colloidal pectin bismuth omeprazole in the treatment of reflux esophagitis is better than omeprazole alone.