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已知本可松常用量静脉注射引起轻度脉搏增快和血压上升。最近有报道在支气管哮喘和嗜铬细胞瘤麻醉时使用本可松(PANC)发生异常的高血压,作者认为其机制为儿茶酚胺分泌增加与本可松相互作用。本可松对循环系的影响,目前有各种解释,一是毒蕈碱受体的阻断作用,该药作用于后接合膜,有阻滞毒蕈碱受体作用与交感神经节的抑制性,中间神经元阻滞SIF(小的强萤光的)细胞的毒蕈碱受体。二是促使交感神经末稍去甲肾上腺素的释放作用。三是在交感神经节后纤维末端阻止去甲肾上腺素的作用。四是对心肌的直接β作用。给本可松全身末稍血管阻力增加,其理由之一是药物直接作用于末稍血管。
It is known that the usual amount of intravenous injection can cause mild pulse and blood pressure to rise faster. It has recently been reported that hypertension that occurs when using Pranopustin (PANC) is associated with bronchial asthma and pheochromocytoma anesthesia and the authors suggest that its mechanism is an increase in catecholamine secretion that interacts with prednisone. Bencicone on the impact of the circulatory system, there are various explanations, one is the blockade of muscarinic receptors, the drug role in the post-conjunctiva, block the role of muscarinic receptors and sympathetic ganglia inhibition Sexual, interneurons block muscarinic receptors in SIF (small, strongly fluorescent) cells. The second is to promote the release of sympathetic terminal norepinephrine. The third is to prevent norepinephrine at the end of the sympathetic ganglion fibers. Fourth, direct myocardial β role. One of the reasons for the increase in systemic vascular resistance attributed to this prednisone is the direct effect of the drug on the distal vessels.