1980年,Weissenbach等~([1])在研究人成纤维细胞β干扰素(interferonβ,IFN-β)时,首次发现一种相对分子质量(Mr)约为26 000的蛋白,当时将其命名为IFN-β2,直到1989年,在纽约召开的“急性期反应和免疫应答的调控:新的细胞因子”会议中将其命名为白细胞介素6(interleukin 6,IL-6),并一直沿用至今~([2])。IL-6是一种多效性细胞因子,由巨噬细胞 In 1980, Weissenbach et al. ([1]) first found a protein with a relative molecular mass (Mr) of about 26 000 when studying human fibroblast interferon beta (IFN-β) Is IFN-β2, which was named as Interleukin 6 (IL-6) in the conference “Regulation of Acute Reactions and Immune Responses: New Cytokines” held in New York City until 1989. Has been in use ~ ([2]). IL-6 is a pleiotropic cytokine produced by macrophages