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目的 观察恶性消化系肿瘤晚期患者空腹和服糖后血糖及乳酸变化,探讨消化系恶性肿瘤晚期患者糖代谢 紊乱表现及其机理。方法 测定45例恶性消化系肿瘤晚期患者和45例健康体检正常人员空腹血糖、空腹乳酸、 服糖2h后血糖和乳酸含量,并计算服糖2h后血糖和乳酸含量与空腹血糖和乳酸含量比值。结果 恶性肿瘤晚 期患者空腹乳酸、服糖2h后血糖和乳酸含量均明显高于正常对照组(P<0.01);服糖2h后血糖与空腹血糖比值 以及服糖2h后乳酸与空腹乳酸比值,明显高于正常对照组(P<0.01)。恶性消化系肿瘤晚期患者空腹血糖与正 常对照组无显著性差异(P>0.05)。结论 恶性消化系肿瘤晚期患者尽管空腹血糖正常,但仍存在糖代谢紊乱。 糖代谢紊乱主要表现为空腹高乳酸血症和服糖后高血糖和高乳酸反应。
Objective To observe the changes of fasting glucose and post-glucose glucose and lactic acid in patients with advanced malignant digestive tumors, and to explore the manifestation and mechanism of glucose metabolism disorders in patients with advanced malignant tumors of the digestive system. Methods The fasting blood glucose, fasting lactic acid, and glucose and lactate content were measured in 45 patients with advanced malignant digestive tumors and 45 healthy subjects. The blood glucose and lactate contents were compared with those of fasting blood glucose and lactic acid after serving glucose for 2 hours. Results The fasting lactate and sugar content of patients with advanced malignant tumors were significantly higher than those of normal control group after 2h (P<0.01); the ratio of blood glucose and fasting blood glucose after serving 2h and the ratio of lactate to fasting lactate after serving 2h were obvious. Higher than the normal control group (P <0.01). There was no significant difference between fasting blood glucose and normal control group in patients with advanced malignant digestive tumor (P>0.05). Conclusions Patients with advanced malignant digestive tumors have normal glucose metabolism, but they still have glucose metabolism disorder. Disorders of glucose metabolism mainly include fasting hyperlactatemia and post-sugar hyperglycemia and high lactate reaction.