论文部分内容阅读
类风湿关节炎(RA)是一种以慢性滑膜炎、关节软骨及骨质破坏、关节畸形及功能丧失等为主要特征的自身免疫性疾病,其病因和发病机制尚不明确,尚无特效的治疗方法。生物标记物作为重要的辅助诊疗指标,已广泛应用于RA的诊断、分型以及预后评估等诊疗过程中。蛋白类生物标记物是最早应用于临床的RA诊断标记物,炎性细胞因子水平对RA影响的研究也不断取得进展,近年来肠道菌群与RA的相关性也引起研究者的广泛关注。本文简要综述RA的蛋白类生物标记物、炎性细胞因子与RA的关系以及其他标记物的研究进展,旨在为RA的多途径、多因素早期发现RA,精准治疗RA提供理论参考。
Rheumatoid arthritis (RA) is an autoimmune disease mainly characterized by chronic synovitis, articular cartilage and bone destruction, joint deformity and loss of function. The etiology and pathogenesis of rheumatoid arthritis (RA) is not clear and there is no specific effect The treatment. Biomarkers as an important adjuvant treatment indicators, has been widely used in the diagnosis of RA, classification and prognosis assessment and other treatment process. Protein biomarkers are the earliest clinical diagnostic markers of RA. The research on the influence of inflammatory cytokines on RA is also making continuous progress. In recent years, the correlation between intestinal microflora and RA has also drawn the attention of researchers. This review summarizes the research progress of the RA protein biomarkers, the relationship between inflammatory cytokines and RA and other markers in order to provide a theoretical reference for the early detection of RA and the accurate treatment of RA by multiple and multiple factors.