慢性脑缺血是血管性痴呆、Alzheimer病(AD)和Binswanger病等多种疾病的共同病理过程,以持久或进展性认知功能障碍为主要表现[1]。随着凋亡、免疫炎症、氧化应激损伤、突触结构、功能异常、能量障碍、中枢胆碱能、单胺能系统功能的缺损等病理机制的明确,针对上述机制的治疗研究 Chronic cerebral ischemia is a common pathological process of many diseases such as vascular dementia, Alzheimer’s disease (AD) and Binswanger’s disease, with persistent or progressive cognitive dysfunction as the main manifestation. With the pathogenesis of apoptosis, immune inflammation, oxidative stress injury, synaptic structure, dysfunction, energy disorders, central cholinergic, monoamine dysfunction and other pathological mechanisms clear, the treatment of these mechanisms