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目的观察以PPI为基础联合二种抗生素加铋剂的四联疗法治疗幽门螺旋杆菌(Hp)感染的疗效。方法选取68例Hp感染患者,随机分成治疗组34例和对照组34例,治疗组给予以PPI为基础联合二种抗生素加铋剂的四联疗法,对照组给予以PPI为基础联合二种抗生素的三联疗法,疗程均为14 d,疗程结束4周后,复查Hp,必要时复查胃镜,观察Hp根除率、临床症状缓解率及不良反应情况。结果治疗组Hp根除率为88.2%,对照组Hp根除率为64.7%,两组比较差异有统计学意义(P<0.01),治疗组临床症状缓解率为85.3%,不良反应发生率为23.5%,对照组临床症状缓解率为79.4%,不良反应发生率为17.6%,两组比较差异未见统计学意义(P>0.05)。结论比较四联疗法与三联疗法治疗幽门螺旋杆菌感染的效果,在临床症状缓解率、不良反应发生率方面两种方法基本相同,但四联疗法具有更好的Hp根除率。
Objective To observe the efficacy of quadruple therapy based on PPI combined with two antibiotics and bismuth in the treatment of Helicobacter pylori (Hp) infection. Methods Sixty-eight patients with Hp infection were selected and randomly divided into treatment group (34 cases) and control group (34 cases). Patients in the treatment group were given PPI-based quadruple therapy combined with two antibiotics plus bismuth. In the control group, PPI-based combined two antibiotics Of the triple therapy, treatment were 14 d, 4 weeks after the end of treatment, review Hp, if necessary, review of gastroscope, observation of Hp eradication rate, clinical symptoms and adverse reactions. Results Hp eradication rate was 88.2% in the treatment group and Hp eradication rate was 64.7% in the control group, with significant difference between the two groups (P <0.01). The clinical symptom relief rate was 85.3% and the adverse reaction rate was 23.5% , The response rate of clinical symptoms in the control group was 79.4% and the incidence of adverse reactions was 17.6%. There was no significant difference between the two groups (P> 0.05). Conclusions Compared with triple therapy and triple therapy in the treatment of H. pylori infection, the two methods are basically the same in clinical symptom response rate and adverse reaction rate, but quadruple therapy has better Hp eradication rate.