致痫灶切除术是治疗局灶性顽固性癫痫的有效方法。神经影像学检查、尤其是高分辨率MRI,能够发现一些癫痫患者脑内的局灶性病理性改变,为手术提供依据。然而,有相当一部分的癫痫患者,脑影像学检查难以发现明确的病灶,称之为非病灶性癫痫(non lesionalepilepsy)或影像学阴性表现 Epileptogenic resection is an effective method for the treatment of focal intractable epilepsy. Neuroimaging, especially high-resolution MRI, can find focal pathological changes in the brain of some patients with epilepsy, providing a basis for surgery. However, a significant proportion of patients with epilepsy have difficulty finding a definite lesion on brain imaging and are referred to as non-lesionalepilepsy or imaging negative findings