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目的探讨胎盘多肽(PPs)联合重组人粒细胞集落刺激因子(rhG-CSF)治疗非老年成人急性髓细胞性白血病的疗效。方法 2009年3月-2012年10月初诊、巩固治疗的Ⅰ期急性髓细胞白血病(AML)患者共113例。通过不同剂量rhG-CSF分组及联用或不联用胎盘多肽,评估患者的疗效及骨髓有核细胞、中性粒细胞恢复程度。结果胎盘多肽及rhG-CSF可促进骨髓有核细胞增殖及缩短ANC恢复时间,且两者联用效果优于单用此两种药物;联用胎盘多肽可降低rhG-CSF使用剂量且取得相同疗效,而rhG-CSF副作用则明显减轻。结论胎盘多肽联用rhG-CSF可减轻非老年性成人AML患者经济负担、提高rhG-CSF疗效及安全性,从而使此类患者受益。
Objective To investigate the efficacy of placental polypeptide (PPs) combined with recombinant human granulocyte colony-stimulating factor (rhG-CSF) in the treatment of non-aged adult patients with acute myeloid leukemia. Methods A total of 113 patients with stage Ⅰ acute myeloid leukemia (AML) were recruited from March 2009 to October 2012. Through different doses of rhG-CSF group with and without the combination of placental peptides to assess the efficacy of patients and bone marrow nucleated cells, the degree of neutrophil recovery. Results Placental peptide and rhG-CSF could promote the proliferation of bone marrow mononuclear cells and shorten the recovery time of ANC, and the combined effect of the two drugs was better than that of the two drugs alone. Combined use of placental peptide could reduce the dose of rhG-CSF and achieve the same effect , While rhG-CSF side effects were significantly reduced. Conclusion Placental peptide combined with rhG-CSF can reduce the economic burden of non-elderly adults with AML and improve the efficacy and safety of rhG-CSF.