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本实验研究了丙烯胺所致大鼠心肌坏死的发生机理。结果发现预先给动物注射异搏停或心得安均不能减轻丙烯胺所致心肌坏死程度,而预先投予单胺氧化酶抑制剂羟胺或氨基脲可明显减轻丙烯胺引起的心肌坏死程度。研究结果表明,丙烯胺所致心肌坏死可能涉及单胺氧化酶系统。
This study investigated the mechanism of acrylamide-induced myocardial necrosis in rats. The results showed that pre-injection of verapamil or propranolol did not reduce the degree of myocardial necrosis caused by acrylamide, and pre-administration of monoamine oxidase inhibitors hydroxylamine or semicarbazide can significantly reduce the degree of myocardial necrosis caused by acrylamide. The results show that acrylamide induced myocardial necrosis may involve monoamine oxidase system.