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本文报道了22例放射性皮肤损伤晚期的组织病理学的观察结果。职业性皮肤损伤8例。主要病变为增生性皮炎,表皮明显增生伴有过度角化,其中2例局部表皮见不典型增生,1例恶性变为鳞形细胞癌。医源性皮肤损伤11例和事故性皮肤损伤3例,主要病变为放射性纤维化和表皮溃疡形成,真皮内小动脉壁纤维性增厚,皮肤附件也多消失。慢性放射性皮肤损伤的恶性变主要见于职业性损伤者。经过对恶性变病例长期随访后认为,早期发现皮肤癌及时手术切除是十分必要的。放射性皮肤损伤的组织病理学研究国外早已有报道。近年来,国内也有这方面的报道。本文着重介绍不同致伤原因造成放射性皮肤损伤晚期的组织病理学改变。
This article reports 22 cases of radioactive skin lesions late histopathological observations. Occupational skin injury in 8 cases. The main lesion was proliferative dermatitis, epidermal hyperplasia accompanied by hyperkeratosis, of which 2 cases of local epidermis see atypical hyperplasia, 1 case of malignant to squamous cell carcinoma. Iatrogenic skin injury in 11 cases and accidental skin injury in 3 cases, the main lesions of radiation fibrosis and formation of epidermal ulcers, intra-dermal arteriolar fibrosis, skin appendages and more disappear. Malignant changes in chronic radiation-induced skin lesions are mainly seen in occupational injuries. After long-term follow-up of malignant transformation cases that early detection of skin cancer timely surgical removal is very necessary. Histopathological studies of radioactive skin lesions have long been reported abroad. In recent years, there are also reports in this area. This article focuses on the different pathological causes of injury caused by the late stage of radioactive skin lesions histopathological changes.