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目的以缓释与矫味为目的,制备黄连总生物碱载药树脂药物复合物,分析黄连总生物碱的载药树脂的含量及溶出度。方法建立RP-HPLC方法,测定不同批次黄连总生物碱载药树脂的质量,同时评价黄连总生物碱载药树脂在水、人工胃液、人工肠液中的释放情况。结果所制备的不同批次的黄连总生物碱载药树脂中总生物碱的含量为65.68%~68.91%,RSD为2.22%。黄连总生物碱载药树脂经1h在水、人工胃液、人工肠液中的累计释放度分别为8.6%、80.2%、77.3%。结论所制备的黄连总生物碱载药树脂中总生物碱含量稳定。黄连总生物碱载药树脂在水中释放量小,在人工胃液、人工肠液中释放度均大于75%,可起到一定缓释与矫味剂的双重作用。
OBJECTIVE To prepare sustained-release and flavorsome for the preparation of Coptis chinensis alkaloids loaded drug-resin complexes, and to analyze the content and dissolution of drug-loaded resins of Coptis chinensis alkaloids. Methods RP-HPLC method was established to determine the quality of different batches of Coptis alkaloids drug-loaded resin. Meanwhile, the release of Coptis alkaloids loaded resin in water, artificial gastric juice and artificial intestinal juice was evaluated. Results The results showed that the total alkaloids content in the different kinds of Coptis alkaloids loaded resin was 65.68% -68.91% with RSD of 2.22%. Coptis total alkaloids loaded resin by 1h in water, artificial gastric juice, artificial intestinal fluid cumulative release were 8.6%, 80.2%, 77.3%. Conclusion The content of total alkaloids in Coptis alkaloids loaded resin is stable. Coptis total alkaloids loaded resin release in water is small, in the artificial gastric juice, artificial intestinal fluid release degree of more than 75%, can play a certain role in slow release and flavoring agent.