论文部分内容阅读
癫是多种原因导致的脑部神经元高度同步化异常放电所致的临床综合征,癫是一种慢性疾病,可迁延数年、数十年乃至整个生命过程,因而对患者身体、精神、婚姻以及社会经济地位等造成严重的不良影响。据统计,我国目前约有900万以上的癫患者,每年新发的癫患者65~70万,其死亡率为1.3~3.6/10万。目前针对癫的发病机制仍不十分清楚,虽有一些新的癫药物的问世,但癫的治疗仍然很困难,相关研究一直是本领域的热点,因此建立癫模型并以此来研究癫的发病机制及筛选合适的药物治疗显得尤为重要。癫模型包括动物体内模型和离体模型。自从
Epilepsy is caused by a variety of reasons, the brain neurons highly synchronized abnormal discharge caused by clinical syndrome, epilepsy is a chronic disease that can be extended for several years, decades and even the entire life process, and thus the patient’s body, Mental, marital and socio-economic status have serious adverse effects. According to statistics, there are about 9 million patients with epilepsy in our country. The annual incidence of new epilepsy is 65 to 700,000 with a mortality rate of 1.3 to 3.6 / 100,000. At present, the pathogenesis of epilepsy remains unclear. Although some new epilepsy drugs are available, the treatment of epilepsy is still very difficult. The related research has been a hot spot in this field. Therefore, to establish the epilepsy model It is particularly important to study the pathogenesis of epilepsy and screen the appropriate drug treatment. Epilepsy models include in vivo animal models and in vitro models. since