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在绵羊、山羊、牛、猪和马等单或多排卵动物中通过抑制素免疫诱发多重排卵已得到一致的结果。被动抑制素免疫在单排卵动物如牛和马及多排卵动物如大鼠和仓鼠也诱发排卵过速。对性成熟期豚鼠给予主动抑制素免疫,以测定中和内源性抑制素是否会影响滤泡的发育和排卵率。 18只3月龄雌性豚鼠经过植入黄体酮4周后分为3组。去除孕酮(P)1周后豚鼠在4周内皮下注射1ml安慰剂、25μg或50μg抑制素疫苗3次。试验期间每周收集1次血样用于检测抑制素抗体滴度。第3次注射抑制素疫苗后,在动情期后第8天
Consensus results have been obtained by inducing multiple ovulation by inhibin immunization in single or multiple ovulation animals such as sheep, goats, cattle, pigs and horses. Passive inhibin immunization also triggers ovulation hypersensitivity in mono-ovulated animals such as cattle and horses and multiple ovulation animals such as rats and hamsters. Proactive inhibin immunization of sexually mature guinea pigs was performed to determine if neutralizing endogenous inhibin affects follicular development and ovulation. Eighteen 3-month-old female guinea pigs were divided into 3 groups after 4 weeks of implantation of progesterone. Guinea pigs were subcutaneously injected with 1 ml placebo, 25 [mu] g or 50 [mu] g inhibin vaccine 3 times 4 weeks after removal of progesterone (P) 1 week. Blood samples were collected weekly for test inhibin antibody titers during the trial. After the 3rd injection of inhibin vaccine, on the 8th day after estrus