再生障碍性贫血(再障)是一种死亡率高的严重疾病,生存曲线示双相形,即自起病至约3-6个月,曲线呈陡坡状下降,此后则呈较平坦的下降,表明再障存在不同类型:具有迅速致命病程的急性型及延续数月甚至数年、死亡率较低或最终存活的慢性型。为选择最适宜的治疗途径,需有可靠的预后因素。近几年来,曾试图建立预测再障病人生存的方法。作者通过38例获得性再障病人的观察,研究了各种预后因素的价值。所有病例观察直到死亡或自诊断后随访4年以上。38例患者中估计有毒物接触者27例,其中主要毒物为氯霉素者11例,为吡唑酮衍化物者6例。发病前6个月内患肝炎的2例。38例中,以雄性激素作为主要治疗的有25例,此外,根据情况需要,给予红细胞与血小板 Aplastic anemia (aplastic anemia) is a serious disease with a high mortality rate. The survival curve shows a biphasic pattern, that is, from the onset to the age of about 3-6 months, the curve decreases steeply and then decreases more flatly. This suggests that there are different types of aplasia: acute forms with a rapidly fatal course and chronic forms with months or even years of persistence, lower mortality or eventually survival. In order to choose the most appropriate treatment, there must be a reliable prognostic factor. In recent years, attempts have been made to establish a method of predicting the survival of aplastic anemia patients. By observing 38 patients with acquired aplastic anemia, the authors investigated the value of various prognostic factors. All cases were observed until death or after 4 years of follow-up after diagnosis. Among the 38 patients, 27 were estimated to have toxic contacts, of which 11 were chloramphenicol and 6 were pyrazolone derivatives. In the first 6 months before onset of hepatitis in 2 cases. Of the 38 patients, 25 were treated with androgens as their primary treatment. In addition, as required, red blood cells and platelets