目的探讨肾病综合征患者血清CA125的水平及其产生的原因。方法CA125测定采用化学发光标记免疫法(CLIA)。共测定了肾病综合征患者27例(分为两组:一组为伴有浆膜腔积液14例,另一组为不伴有浆膜腔积液13例)、正常对照组20人。结果伴有浆膜腔积液组血清CA125水平显著高于不伴有浆膜腔积液组及正常对照组(均P<0.05)。结论伴有浆膜腔积液的肾病综合征患者的血清CA125会升高,其原因可能与肾病综合征并发的胸、腹水等有关。 Objective To investigate the level of serum CA125 in patients with nephrotic syndrome and its causes. Methods CA125 was determined by chemiluminescence immunoassay (CLIA). A total of 27 patients with nephrotic syndrome (divided into two groups: one group with 14 cases of serous effusion and the other group without serous effusion in 13 cases), the normal control group of 20 people. Results The level of serum CA125 in patients with serosal effusion was significantly higher than those without serous effusion and normal controls (all P <0.05). Conclusions Patients with nephrotic syndrome with serous effusions may have elevated serum CA125, which may be related to thoracic and ascitic fluid associated with nephrotic syndrome.