论文部分内容阅读
目的分析采用三维适形同步增量照射(SIB-CRT)与适形序贯增量(SB-CRT)在脑转移瘤治疗中的疗效。方法选择2010年4月至2012年4月本院56例非小细胞肺癌脑转移患者。同步组29例患者采用全脑放疗PTV 36Gy/20 f同步转移灶适形放疗PGTV 15 Gy/10 f,序贯组27例患者采用先给予全脑放疗PTV 40 Gy/20 f后,缩野至转移灶PGTV 20 Gy/10 f。通过对近远期疗效,不良反应的观察对比,分析其疗效。结果随访到52例患者,4例失访,随访期3~48个月。同步组肿瘤控制率81.4%,中位生存期为12.3个月,KPS评分3个月80分以上占55.5%,序贯组肿瘤控制率76%,中位生存期为10.4个月,KPS评分3个月80分以上占40%。结论三维适形同步增量照射较适形序贯增量更为有效,能提高患者的生存质量,减少放射损伤,延长生存时间。
Objective To evaluate the efficacy of three-dimensional conformal synchronous incremental irradiation (SIB-CRT) and conformal sequential augmentation (SB-CRT) in the treatment of brain metastases. Methods From April 2010 to April 2012, 56 patients with brain metastases from non-small cell lung cancer were selected. Twenty-nine patients in the synchronization group received PTV 36Gy / 20 f synchronic metastasis congenital radiotherapy (PGV) of 15 Gy / 10 f for whole brain radiotherapy. Twenty-seven patients in the sequential group were treated with PTV 40 Gy / 20 f Metastatic PGTV 20 Gy / 10 f. Through the short-term efficacy, adverse reactions were observed and compared to analyze its efficacy. Results Follow-up to 52 patients, 4 were lost to follow-up period of 3 to 48 months. The control group had a tumor control rate of 81.4%, a median survival time of 12.3 months, a KPS score of 80% or more at 3 months and a sequential control group of 76% with a median survival of 10.4 months and a KPS score of 3 80% of the month or more accounted for 40%. Conclusions The three-dimensional conformal synchronous incremental irradiation is more effective than the conformal sequential incremental, which can improve the quality of life of patients, reduce radiation injury and extend the survival time.