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目的研究GNAS1基因T393C多态性与肾透明细胞癌的临床分期和病理分级的关系。方法收集42例手术切除肾透明细胞癌的标本,应用PCR-限制性片段长度多态性法,对肾透明细胞癌患者和健康查体者进行基因多态性的比较。结果在GNAS1基因T393C多态性与肾透明细胞癌的病理分级及临床分期无明显相关性(P>0.05)。结论 GNAS1基因T393C多态性与肾透明细胞癌的临床分期及病理分级无明显相关关系。
Objective To investigate the relationship between T393C polymorphism of GNAS1 gene and the clinical stage and pathological grade of clear cell renal cell carcinoma (RCC). Methods 42 cases of clear cell carcinoma of the kidney were collected and the polymorphism of the gene was analyzed by PCR-restriction fragment length polymorphism (PCR-RFLP). Results There was no significant correlation between T393C polymorphism of GNAS1 gene and pathological grading and clinical stage of clear cell renal cell carcinoma (P> 0.05). Conclusion There is no significant correlation between T393C polymorphism of GNAS1 gene and clinical stage and pathological grade of clear cell renal cell carcinoma.