论文部分内容阅读
目的探讨辛伐他汀对短暂性脑缺血发作(TIA)患者颈动脉粥样硬化斑块和血脂的影响。方法选取武汉市汉阳医院2012年3月—2015年5月收治的70例TIA患者,随机分为对照组和观察组,各35例。对照组给予阿司匹林肠溶片治疗,观察组在对照组治疗基础上加用辛伐他汀口服治疗。比较两组治疗前后颈动脉内-中膜厚度(IMT)、动脉粥样硬化斑块面积、血脂指标及治疗期间脑血管事件发生率。结果治疗前两组患者IMT、动脉粥样硬化斑块面积比较,差异无统计学意义(P>0.05);治疗后观察组IMT、动脉粥样硬化斑块面积小于对照组,差异有统计学意义(P<0.05)。治疗前两组患者血脂指标比较,差异无统计学意义(P>0.05);治疗后观察组总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)水平低于对照组,高密度脂蛋白(HDL)水平高于对照组,差异有统计学意义(P<0.05)。观察组脑血管事件发生率低于对照组,差异有统计学意义(P<0.05)。结论辛伐他汀可明显改善TIA患者血脂代谢,有效改善或稳定颈动脉粥样硬化斑块,明显降低脑血管事件发生率,改善患者预后。
Objective To investigate the effect of simvastatin on carotid atherosclerosis plaque and serum lipids in patients with transient ischemic attack (TIA). Methods Seventy patients with TIA admitted to Wuhan Hanyang Hospital from March 2012 to May 2015 were randomly divided into control group and observation group, with 35 cases in each group. The control group was given aspirin enteric-coated tablets. The observation group was treated with simvastatin orally on the basis of the control group. Carotid IMT, area of atherosclerotic plaque, blood lipid index and the incidence of cerebrovascular events during the treatment were compared between the two groups before and after treatment. Results There was no significant difference in IMT and atherosclerotic plaque area between the two groups before treatment (P> 0.05). After treatment, the area of IMT and atherosclerotic plaque in the observation group was smaller than that in the control group, the difference was statistically significant (P <0.05). The levels of TC, TG and LDL in the two groups before treatment were significantly lower than those in the control group (P> 0.05) High-density lipoprotein (HDL) levels higher than the control group, the difference was statistically significant (P <0.05). The incidence of cerebrovascular events in the observation group was lower than that in the control group, with significant difference (P <0.05). Conclusion Simvastatin can significantly improve blood lipid metabolism in patients with TIA, effectively improve or stabilize the carotid atherosclerosis plaque, significantly reduce the incidence of cerebrovascular events and improve the prognosis of patients.