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对70例正常人及127例原发性高血压病人肾素、血管紧张素、醛固酮及心钠素水平的分析及相互关系进行探讨。结果表明:1.高血压组心钠素水平明显低于正常对照组。2.高血压患者的肾素与心钠素水平呈负相关(r=-0.229,P<0.05);在肾素分型及血管紧张素Ⅱ分型中,高肾素型及高血管紧张素Ⅱ型高血压患者肾素及血管紧张素Ⅱ和心钠素水平呈显著负相关(r=-0.85,P<0.01;r=-0.526,P<0.01),提示血浆心钠素降低,肾素、血管紧张素Ⅱ水平升高以及心钠素对肾素、血管紧张素Ⅱ拮抗作用的减弱可能是原发性高血压病人重要的病理调节机制之一。3.本文原发性高血压病人血压升高程度与心钠素、肾素、血管紧张素Ⅱ水平未见明显相关性,可能与高肾素组病人心钠素水平低于低肾素组,以及低肾素组病人心钠素水平高于高肾素组有关。其血压升高程度可能部分取决于二者的平衡制约状态及与外周阻力血管(靶器官)受体对于肾素-血管紧张素-醛固酮系统及心钠素的敏感性有关。
The levels of renin, angiotensin, aldosterone and atrial natriuretic peptide in 70 normal subjects and 127 patients with essential hypertension were analyzed and their correlations were analyzed. The results showed that: 1. The atrial natriuretic peptide level in hypertension group was significantly lower than that in normal control group. There was a negative correlation between renin and atrial natriuretic peptide in hypertensive patients (r = -0.229, P <0.05). In renin type and angiotensin Ⅱ type, high renin and high angiotensin There was a significant negative correlation between renin, angiotensin Ⅱ and atrial natriuretic peptide in patients with type Ⅱ hypertension (r = -0.85, P <0.01; r = -0.526, P <0.01), suggesting that plasma atrial natriuretic peptide , And the increase of angiotensin Ⅱ and the decrease of antagonism of atrial natriuretic peptide and atrial natriuretic peptide may be one of the important pathological mechanisms in patients with essential hypertension. This article hypertensive patients with hypertension and atrial natriuretic peptide, renin, angiotensin Ⅱ level no significant correlation, may be associated with high renin group patients with atrial natriuretic peptide levels lower than the low renin group, And patients with low renin group atrial natriuretic peptide levels higher than the high renin group. The increase in blood pressure may depend in part on the balance of the two and on the sensitivity of the peripheral vascular (target organ) receptors to the renin-angiotensin-aldosterone system and atrial natriuretic peptide.