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尽管二叶式主动脉瓣(BAV)患者易患升主动脉(AA)扩张、狭窄和夹层,但对BAV患儿主动脉疾病的进展情况却鲜有记载。本研究的目的是确定BA V患儿AA直径的变化速率,并探讨主动脉扩张进展的危险因素。回顾性分析了276例年龄<19岁(平均8.5±5.3岁)孤立性BAV患儿的超声心动图资料。将主动脉测量结果用体表面积标化为z分数。在包括112例接受连续检查的患者的亚组中,计算主动脉扩张速率,并确定加速主动脉扩张的危险因素。最初时,33例(12%)患者有显著的AA扩张(z>4),70例(25%)为轻度异常(z在2～4之间)
Although patients with bipolar aortic valve (BAV) are predisposed to the expansion, stenosis, and dissection of the ascending aorta (AA), the progression of aortic disease in children with BAV is seldom documented. The purpose of this study was to determine the rate of change of AA diameter in children with BA V and to explore the risk factors for the progression of aortic dilatation. Echocardiographic data were retrospectively analyzed for 276 pediatric BAV children aged <19 years (mean 8.5 ± 5.3 years) with solitary BAV. Aortic measurements were normalized to z fractions using body surface area. In a subset of 112 patients undergoing consecutive examinations, the aortic dilatation rate was calculated and the risk factors for accelerated aortic dilatation were determined. Initially, 33 patients (12%) had significant AA dilation (z> 4) and 70 (25%) had mild abnormalities (z was between 2 and 4)