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目的对比急性期川崎病与猩红热患儿血浆N端脑钠肽前体(N-terminal pro-brain natriuretic,NT-pro BNP)水平,以探讨NT-pro BNP在二者鉴别诊断中的意义。方法选取2013年12月—2015年4月本院收治的49例川崎病患儿纳入A组,同期的27例猩红热患儿纳入B组,两组在入院时(正式治疗前)均检测NT-pro BNP、WBC、CRP、ESR 4项指标并进行两组之间的对比。计量资料采用t检验,P<0.05为差异有统计学意义。结果 A组NT-pro BNP水平为(872.94±54.30)pg/ml,B组为(95.30±18.20)pg/ml,两组间比较差异有统计学意义(P<0.05),而两组WBC、CRP及ESR对比差异均无统计学意义(均P>0.05)。结论 NT-pro BNP水平在川崎病与猩红热间有鉴别意义,而WBC、CRP、ESR则无鉴别意义。
Objective To compare the plasma N-terminal pro-brain natriuretic (NT-pro BNP) levels in children with acute Kawasaki disease and scarlet fever in order to explore the significance of NT-pro BNP in the differential diagnosis between the two. Methods 49 cases of Kawasaki disease admitted to our hospital from December 2013 to April 2015 were enrolled in group A and 27 cases of scarlet fever were enrolled in group B. Patients in both groups were admitted to hospital (before treatment) pro BNP, WBC, CRP, ESR 4 indicators and the comparison between the two groups. Measurement data using t test, P <0.05 for the difference was statistically significant. Results The level of NT-pro BNP in group A was (872.94 ± 54.30) pg / ml and that in group B was (95.30 ± 18.20) pg / ml. There was significant difference between the two groups (P < There was no significant difference between CRP and ESR (all P> 0.05). Conclusion The level of NT-pro BNP is of differential significance between Kawasaki disease and scarlet fever, while WBC, CRP and ESR are of no significance.