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目的:评价鬼臼毒素柔性纳米脂质体凝胶治疗复发性尖锐湿疣的疗效和安全性。方法:选择适合的复发性尖锐湿疣患者,采用鬼臼毒素柔性纳米脂质体凝胶与普通鬼臼毒素凝胶进行随机双盲、对照研究,主要观察近期治疗效果、复发情况及局部不良反应。结果:鬼臼毒素柔性纳米脂质体凝胶对尖锐湿疣的首次清除率(97.1%)与普通鬼臼毒素凝胶剂(90.6%)相近(P>0.05),但复发率和不良反应发生率均低于普通鬼臼毒素凝胶剂(P<0.01)。结论:鬼臼毒素柔性纳米脂质体凝胶局部外用轻微,患者耐受性好,复发率低。
Objective: To evaluate the efficacy and safety of podophyllotoxin flexible nano-liposome gel in the treatment of recurrent condyloma acuminatum. Methods: The patients with recurrent condyloma acuminatum were selected and randomized double-blind and controlled study was conducted with podophyllotoxin flexible nano-liposome gel and ordinary podophyllotoxin gel. The main treatment effects, recurrence and local adverse reactions were observed. Results: The first clearance rate of podophyllotoxin flexible nano-liposome gel for condyloma acuminatum (97.1%) was similar to that of common podophyllotoxin gel (90.6%) (P> 0.05), but the recurrence rate and adverse reaction rate Lower than that of ordinary podophyllotoxin gels (P <0.01). CONCLUSION: The podophyllotoxin flexible nano-liposome gel has slight local topical application, good patient tolerance and low recurrence rate.