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目的观察香菇多糖联合顺铂及紫杉醇治疗老年卵巢癌并腹水患者的临床疗效。方法将93例老年卵巢癌并腹水患者随机分为对照组和观察组,对照组予以顺铂联合紫杉醇化疗,观察组在化疗的基础上予以香菇多糖治疗,评价其治疗效果。结果对照组近期有效率为53.66%,疾病控制率为87.80%;观察组近期有效率为84.61%,疾病控制率为100%,两组比较差异有统计学意义(P<0.05)。观察组不良反应较轻,发生率减少。结论香菇多糖联合化疗能增强化疗疗效,对老年中晚期卵巢癌合并腹水的患者有抑制实体瘤生长和控制恶性腹水的治疗效果。
Objective To observe the clinical efficacy of lentinan combined with cisplatin and paclitaxel in the treatment of elderly patients with ovarian cancer and ascites. Methods Ninety-three elderly patients with ovarian cancer and ascites were randomly divided into control group and observation group. The control group was treated with cisplatin and paclitaxel. The observation group was treated with lentinan on the basis of chemotherapy, and the therapeutic effect was evaluated. Results The effective rate of the control group was 53.66% and the disease control rate was 87.80%. The effective rate of the observation group was 84.61% and the disease control rate was 100%. The difference between the two groups was statistically significant (P <0.05). Adverse reactions in the observation group were lighter and the incidence decreased. Conclusions Lentinan combined with chemotherapy can enhance the curative effect of chemotherapy. The treatment of advanced asymptomatic ovarian cancer patients with ascites has the effect of inhibiting solid tumor growth and controlling malignant ascites.