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Objective:To investigate the effect of Shenqi Compound Formula(SCF)on peroxisome proliferatorsactivated receptor γ,(PPARγ)in white adipose tissue of rats with macrovascular lesion in early stage of diabetes.Methods:Corresponding treatment was given to rats in model group,Ramipril group,normal control group,low dosage SCF group and high dosage SCF group respectively for 32 days.The expressions of PPARγand adiponectin Messenger RNA(mRNA)were detected by real-time reverse transcriptase polymerase chain reaction.Results:The expressions of PPARγand adiponectin mRNA increased significantly in both low and high dosage SCF groups as compared with the model group,and a positive linear correlation was found between the expressions of PPARγ and adiponectin mRNA.Conclusions:SCF can prevent macrovascular lesion in early stage of diabetes,which is possibly related with up-regulating expressions of PPARγ and activating PPARγ.